A group of people traveling on a stagecoach find their journey complicated by the threat of Geronimo, and learn something about each other in the process.
As the railroad builders advance unstoppably through the Arizona desert on their way to the sea, Jill arrives in the small town of Flagstone with the intention of starting a new life.
The conflict between a railroader and a stage line owner is being aggravated by bad guys who are sabotaging both sides. Roy and Gabby mediate the conflict and expose the bad guys.
Dusty Gardner, and other Texas ranchers, are driving a herd of cattle to Abilene, Kansas along the Chisholm Trail. Desperate need of water takes them to the Turner ranch, where Belle Turner demands exorbitant prices for the water. Dusty learns that Belle is also trying to oust Mary Lee and Montana Smith from the trading post Mary operates. The sheriff sides with Belle following a fight between the two women. Belle knows there is artesian springs under the land the trading post occupies and intends to get the property by any means.
The James and Younger outlaw gangs ride into town, and it is up to the local marshal, who has lost both his nerve and his gun skills, to stop them.
Dinner time in a remote home of a prairie family turns nightmarish when a band of blood spattered outlaws break through the front door in search of food, horses, and women. Nothing is as it seems in this constantly twisting genre bender.
Wild Bill Saunders recruits a team of paroled convicts to subdue a lawless gang.
Bob arrives looking for the killer of his uncle. When the Sheriff chases him and his partner Rusty, Reno thinks they are the men he is looking for and takes them into his gang. There Bob finds his uncle's gun and knows he has found the right gang. However he realizes the gang has an unknown leader and he sets out to find him.
Tex and his sidekicks arrive to help out his friend Jeffers, a railroad owner, only to find that he has been killed. They quickly run into trouble with an outlaw gang in their attempt to find the mysterious ghost train that supposedly runs on Jeffer's line.
The Dalton gang escape to a nearby town after a train robbery goes south, but they are met by a coven of witches with sinister plans for the unsuspecting outlaws.
Notorious shootist and womanizer Quirt Evans' horse collapses as he passes a Quaker family's home. Quirt has been wounded, and the kindly family takes him in to nurse him back to health against the advice of others. The handsome Evans quickly attracts the affections of their beautiful daughter, Penelope. He develops an affection for the family and their faith, but his troubled past follows him.