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Eccentric consulting detective Sherlock Holmes and Doctor John Watson battle to bring down a new nemesis and unravel a deadly plot that could destroy England.
When a nobleman is threatened by a family curse on his newly inherited estate, detective Sherlock Holmes is hired to investigate.
Sherlock Holmes and Dr. Watson meet as boys in an English Boarding school. Holmes is known for his deductive ability even as a youth, amazing his classmates with his abilities. When they discover a plot to murder a series of British business men by an Egyptian cult, they move to stop it.
Sherlock Holmes and Dr. Watson look into reports that a huge, vicious hound has killed Lord Charles Baskerville and that Lord Henry Baskerville is the next to be killed.
When Dr. Watson tries to apply Sherlock Holmes' method, he quickly discovers that it is harder than it looks.
Holmes and Dr. Watson take on the case of a beautiful woman whose husband has vanished. The investigation proves strange indeed, involving six missing midgets, villainous monks, a Scottish castle, the Loch Ness monster, and covert naval experiments.
Dr. Watson, who served in the English armed forces and was in the Afghan war, retires and returns to his homeland, in England. Since the financial situation of the doctor is very precarious, his long-time friend Mr. Stamford offers him to rent a room in the house at 221-B Baker Street, which is rented by an elderly lady - Mrs. Hudson. The second rented room is already occupied by another gentleman - the mysterious Mr. Sherlock Holmes. Holmes makes an ambiguous impression on Watson. He conducts complex chemical experiments with blood, plays the violin, has the deepest knowledge about cigar ash, London dirt and criminal law, but at the same time demonstrates complete ignorance of well-known truths (for example, the fact that the Earth revolves around the Sun), does not read fiction, as well as books on history and philosophy. At the same time, very strange visitors constantly come to Holmes, and on the table he has portraits of personalities of a disgusting appearance.
Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".
Holmes and Dr. Watson tackle the case of a curse on the Baskerville bloodline in this ABC Movie of the Week adaptation.
Arthur Conan Doyle reveals the story behind Sherlock Holmes and his mysteries by telling about Dr. Joseph Bell, from whom he drew his inspiration, after meeting him as a medical student in Edinburgh. This TV movie served as the pilot for the later released minisseries Murder Rooms: Mysteries of the Real Sherlock Holmes produced by the BBC. The series then picks up with Sir Arthur Conan Doyle's time as a general practitioner in Southsea, solving mysteries with the help of his mentor, Dr Joseph Bell, who is still based in Edinburgh.