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Corporate billionaire Edward Cole and working class mechanic Carter Chambers are worlds apart. At a crossroads in their lives, they share a hospital room and discover they have two things in common: a desire to spend the time they have left doing everything they ever wanted to do and an unrealized need to come to terms with who they are. Together they embark on the road trip of a lifetime, becoming friends along the way and learning to live life to the fullest, with insight and humor.

Mere seconds before the Earth is to be demolished by an alien construction crew, Arthur Dent is swept off the planet by his friend Ford Prefect, a researcher penning a new edition of "The Hitchhiker's Guide to the Galaxy."

Manhattan drag queens Vida Boheme and Noxeema Jackson impress regional judges in competition, securing berths in the Nationals in Los Angeles. When the two meet pathetic drag novice Chi-Chi Rodriguez — one of the losers that evening — the charmed Vida and Noxeema agree to take the hopeless youngster under their joined wing. Soon the three set off on a madcap road trip across America and struggle to make it to Los Angeles in time.

After an Ithaca College student films his one-night stand with a beautiful sorority girl, he discovers one of his friends has accidentally mailed the homemade sex tape to his girlfriend in Austin. In a frenzy, he must borrow a car and hit the road in a desperate bid to intercept the tape.

Two middle-aged men embark on a spiritual journey through Californian wine country. One is an unpublished novelist suffering from depression, and the other is only days away from walking down the aisle.

When Iyay, a single mother, learns that her estranged husband has died, she drags the entire family on a road trip from Cebu to Dumaguete to attend the funeral.

Humbert Humbert is a middle-aged British novelist who is both appalled by and attracted to the vulgarity of American culture. When he comes to stay at the boarding house run by Charlotte Haze, he soon becomes obsessed with Lolita, the woman's teenaged daughter.

Lloyd and Harry are two men whose stupidity is really indescribable. When Mary, a beautiful woman, loses an important suitcase with money before she leaves for Aspen, the two friends (who have found the suitcase) decide to return it to her. After some "adventures" they finally get to Aspen where, using the lost money they live it up and fight for Mary's heart.

A naive Canadian barber who knows US popular culture inside and out meets a flamboyant roadie who needs someone to drive her and her "brother's" corpse from Thunder Bay, Ontario to New Orleans. Chaos ensues after the barber agrees to drive her, the corpse, and the drugs stashed within all the way.

Once called "Father Frank" for his efforts to rescue lives, Frank Pierce sees the ghosts of those he failed to save around every turn. He has tried everything he can to get fired, calling in sick, delaying taking calls where he might have to face one more victim he couldn't help, yet cannot quit the job on his own.

Trucker Rubber Duck and his buddies Pig Pen, Widow Woman and Spider Mike use their CB radios to warn one another of the presence of cops. But conniving Sheriff Wallace is hip to the truckers' tactics, and begins tricking the drivers through his own CB broadcasts. Facing constant harassment from the law, Rubber Duck and his pals use their radios to coordinate a vast convoy and rule the road.