Hello Cheyenne!

A 15-chapter Western serial. The serial involves the mystery of the murder of William Stillman (Wells) and the finding of the heir to his fortune. Silent Joe (Farnum) arrives in an effort to discover the murderer and prove that he is the true heir. He and the heroine Lou (Anderson) have their adventures in the mountainous terrain with its "vanishing trails." They are aided by The Shadow (Orlamond), a demented scientist with his trained dog, and several remarkable, death-dealing inventions.

J. Wesley Pringle and S. S. Thorpe are running against each other for sheriff. Unscrupulous Thorpe has his gang kidnap Pringle to prevent his win but Georgie Hibler, the daughter of Pringle's biggest supporter and her good friend, Fite, whom Pringle had saved from suicide, team up to saves him from the gang. Pringle wins the election and the girl!

Gracia, a half-breed Indian girl, plots with Cons Saunders to steal cattle from Blake because he is oblivious to her charms. With his stock gone, he cannot repay the money he owes his Uncle Benedict, and when Benedict is murdered, Blake is suspected. Because Blake has taken care of Saunders (Cons's father) for the many years he has been without the use of his legs, the latter is finally conscience-stricken and confesses to the crime, thus freeing Blake to marry Diana.

Neil Allison is tricked into assaying some false samples from a young crook's mine. When Neil sees that he has been duped, a quarrel ensues, and Jim Starke, the youth, is stabbed by an unknown assassin. Neil runs away thinking he has committed murder and becomes the unwitting partner of the victim's father.

Dolly Mainard, en route to her father, a major at Fort Blaine, is escorted through dangerous Sioux territory by a cavalry detachment and Army scout Jim Cardigan. When Captain Blackwell offends some braves of Chief Gray Wolf's tribe, Jim is sent ahead to the Indian camp to ask for peace. Imprisoned by the Indians, he sends a message to Blackwell not to advance; Donlin, a renegade scout, tears the note in such a way that the message is distorted, and the entire force is killed. When Jim escapes, he is accused of treason by Blackwell, court-martialed, and sentenced to death; however, he escapes and rescues Dolly, her father, and Blackwell from Donlin's band of renegades. Jim discovers the missing portion of the note in Donlin's hat, proving his innocence. Dolly remains to become his wife.

Three Outlaws came across a stranded baby and must decide to save the child or escape from the law.

The life of Sam Houston, soldier, statesman, patriot and one of the founders of the Republic of Texas, is depicted.

Hell Bent Wade is the victim of an attack in which is wife is killed and daughter kidnapped. A couple of decades later, he is a sheriff known only as the "mysterious rider," because of his nighttime prowls in search of cattle rustlers.

Major Carter, owner of the Sunset mines, reads of a reward offered for Cheyenne Harry if captured. The butler gives him a telegram telling of the flooding of several shafts in his mine. He is soon on the way to the mine in his car. Ruth, his daughter, follows in her roadster.

Before dying, a man's friend asks him to do his best to keep the truth that he was a robber from his son.

The sheriff, Dan Beckham, and his deputy, Bud Cameron, are posting signs offering a reward for the capture of Cheyenne Harry, accused of holding up a Wells Fargo shipment. Shortly after they have tacked the sign to a tree Cheyenne Harry removes it.