Writer Harry Block draws inspiration from people he knows, and from events that happened to him, sometimes causing these people to become alienated from him as a result.
Harold Crick is a lonely IRS agent whose mundane existence is transformed when he hears a mysterious voice narrating his life.
Maria is a student at the university of Essen, Germany, living and working in a gray, unpleasant, and anonymous environment. While she has little problem finding someone for a one night stand, she rebuffs her lovers in such a rude way that they actually don't know what's going on. But what seems to be a negative attitude at first glance is in fact much worse: Maria is suffering from borderline syndrome, a serious psychotic disease that makes her fail to develop a continuous, reliable personality, from her own perspective as well as from the perspective of those she meets. Then one day, she bumps into Jan, a student who falls in love with her without delay. He's awaiting a hard time when he has to learn how hard it is to stay loyal and faithful to a person who, in her own words, "has a different world inside of her head" and who feels that "there is something inside of me that eats me up."
A black police detective must solve a strange case of a kidnapped boy and deal with a big racial protest.
Hard-drinking novelist Zach Hutton spirals out of control after his wife and mistress both leave him. Alone and crippled by a bad case of writer's block, Zach slips in and out of casual relationships and one-night stands, while his drinking becomes more and more severe. With the help of a bartender and his therapist, Zach confronts his demons — women and alcohol.
Jack Manfred is an aspiring writer who to make ends meet, takes a job as a croupier. Jack remains an observer, knowing that everything in life is a gamble and that gamblers are born to lose. Inevitably, he gets sucked into the world of the casino which takes its toll on his relationships and the novel he is writing.
Set in mid-70's, 12-year old Dvir Avni navigates between the equality values of his home-born Kibbutz and the relationship with his undermined mother, whom the Kibbutz members will to denounce.
Larry Donner, an author with a cruel ex-wife, teaches a writing workshop in which one of his students, Owen, is fed up with his domineering mother. When Owen watches a Hitchcock classic that seems to mirror his own life, he decides to put the movie's plot into action and offers to kill Larry's ex-wife, if Larry promises to murder his mom. Before Larry gets a chance to react to the plan, it seems that Owen has already set things in motion.
The true story of Elle France editor Jean-Dominique Bauby, who, in 1995 at the age of 43, suffered a stroke that paralyzed his entire body, except his left eye. Using that eye to blink out his memoir, Bauby eloquently described the aspects of his interior world, from the psychological torment of being trapped inside his body to his imagined stories from lands he'd only visited in his mind.
After returning home from the Vietnam War, veteran Jacob Singer struggles to maintain his sanity. Plagued by hallucinations and flashbacks, Singer rapidly falls apart as the world and people around him morph and twist into disturbing images. His girlfriend, Jezzie, and ex-wife, Sarah, try to help, but to little avail. Even Singer's chiropractor friend, Louis, fails to reach him as he descends into madness.
Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman, Orlean's book, become strangely intertwined as each one's search for passion collides with the others'.